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The development of silica gel chromatography packing has evolved from the first generation of amorphous silica gel to the second generation of polydispersed spherical silica gel, and further to the third generation of perfectly monodispersed spherical silica gel chromatography packing, with increasingly better chromatographic separation performance. Due to its advantages such as good mechanical strength, solvent resistance, controllable specific surface area and pore size, non-swelling and incompressibility, and a surface rich in silanol groups that are easily bonded or modified, silica gel has become one of the most widely used and longest-established high-performance liquid chromatography packings, and is the first choice for laboratory analysis and detection, as well as industrial preparation, separation, and purification of various organic small molecules, chiral drugs, natural products, peptides, antibiotics, and insulin.

QuikSep Silica Gel packing utilizes advanced ultra-pure spherical silica gel base spheres, combined with domestically advanced bonding and unique capping technologies. The silica gel surface has a high bonding rate and complete coverage, providing excellent peak symmetry and high column efficiency during use. Following standardized production processes, it exhibits outstanding performance in batch reproducibility and stability. It is suitable for purifying medium and high polarity substances: peptides, small molecule natural products, heterocyclic compounds, etc.

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Features:

● High mechanical strength, capable of repeated loading, and long service life

● It exhibits good peak symmetry and high column efficiency

● High sample loading capacity and wide pH coverage

● High cost-effectiveness, good batch stability, conducive to scaling up

The following figure shows the comparison of testing standard naphthalene using an imported C18 packing with a pore size of 100?, a particle size of 20-45μm, and QuikSep C18A30 filler from Huideyi Company, pre-packed in a 10×250mm column, under a mobile phase condition of methanol/water=80/20. The results indicate that the column efficiency and peak shape are comparable to the original imported product, making it a preferred alternative to imported products.

Applications:

Separation and purification of tilbopide - QuikSep C8 200? 10μm

After secondary purification using QuikSep C8 packing, the purity of the sample was increased to 99.80%, with the maximum single impurity level at 0.06%。

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